The UCONN Health Center is a 1.5 million sf facility with medical and dental services as well as advanced academic teaching and research venues. The biggest challenge at the facility included balancing the needs of separate and distinct user groups, while creating clear wayfinding around a large and sprawling campus. We began with a detailed wayfinding assessment and continued with the development of a Sign Standards Manual, which included flexible solutions for interior signage, recommendations for adaptive reuse of existing exterior signage and a brand new donor recognition system. Opening in mid-2016, the new University Tower UCONN John Dempsey Hospital features an 11-story patient tower and an expanded emergency department. To accommodate this growth the campus has also included a new parking garage providing convenience for staff and visitors to the hospital.